Potassium Carbonate → HCID 19759988, compound

HRID 1030291Notes

Reaction equation

HRID 1030291 reaction equation
Cl.[NH2:2][C:3]1[CH:9]=[CH:8][C:6]([OH:7])=[CH:5][C:4]=1[OH:10].[F:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=O)=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+]>CN1C(=O)CCC1.O>[F:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]2[O:10][C:4]3[CH:5]=[C:6]([OH:7])[CH:8]=[CH:9][C:3]=3[N:2]=2)=[CH:14][CH:13]=1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 678794-Fluorobenzoyl chlorideHCID 134088224-Aminobenzene-1,3-diol hydrochloride

Product 1

HCID 19759988HCID 19759988, compoundYield 81%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

4-Aminoresorcinol HCl salt (1.61 g) is dissolved in 10 ml of NMP under nitrogen atmosphere. 4-Fluorobenzoyl chloride (1.91 g) is added all at once and the mixture is heated under reflux for approximately 2 hours. After reflux, the mixture is allowed to cool and is diluted with 60 ml of water. Potassium carbonate (3.5 g) is added and the mixture is stirred. The resulting precipitate is filtered and recrystallized from ethanol and water to yield 1.85 g of the above-named product. The product melts at 225° C.-227° C.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for approximately 2 hours
  3. temperatureAfter reflux
  4. temperatureto cool
  5. filtrationThe resulting precipitate is filtered
  6. customrecrystallized from ethanol and water

Sources & evidence

ORD record
ord-a54804e745074727a84266817bbf49eb
Source dataset
uspto-grants-1992_04
Patent number
US05104960

Reaction notes

Loading…