Hydrochloric Acid → HCID 86745684, compound

HRID 1030374Notes

Reaction equation

HRID 1030374 reaction equation
C([O:5][C:6]([CH2:8][O:9][N:10]=[C:11]1[C:20]2[C:15](=[C:16]([CH3:24])[C:17]([CH3:23])=[C:18]([OH:22])[C:19]=2[CH3:21])[O:14][C:13]([CH2:26][O:27][C:28]2[CH:41]=[CH:40][C:31]([CH2:32][CH:33]3[S:37][C:36](=[O:38])[NH:35][C:34]3=[O:39])=[CH:30][CH:29]=2)([CH3:25])[CH2:12]1)=[O:7])(C)(C)C.Cl>O1CCOCC1>[C:6]([CH2:8][O:9][N:10]=[C:11]1[C:20]2[C:15](=[C:16]([CH3:24])[C:17]([CH3:23])=[C:18]([OH:22])[C:19]=2[CH3:21])[O:14][C:13]([CH2:26][O:27][C:28]2[CH:41]=[CH:40][C:31]([CH2:32][CH:33]3[S:37][C:36](=[O:38])[NH:35][C:34]3=[O:39])=[CH:30][CH:29]=2)([CH3:25])[CH2:12]1)([OH:7])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 73654798HCID 73654798, compound

Product 1

HCID 86745684HCID 86745684, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 0.7 g of 5-[4-(4-t-butoxycarbonylmethoxyimino-6-hydroxy-2,5,7,8-tetramethylchroman -2ylmethoxy)benzyl]thiazolidine-2,4-dione (prepared as described in Example 26) and 7 ml of a 4N dioxane solution of hydrogen chloride was allowed to stand at room temperature for 15 hours. At the end of this time, the solvent was distilled off and the residue was washed with warm water to give the title compound, softening at 75°-85° C.

Workup

  1. distillationAt the end of this time, the solvent was distilled off
  2. washthe residue was washed with warm water

Sources & evidence

ORD record
ord-0e105bd4ed8348fcb3c2c80f1dffdad9
Source dataset
uspto-grants-1992_04
Patent number
US05104888

Reaction notes

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