Hydrochloric Acid → HCID 19822201, compound

HRID 1030389Notes

Reaction equation

HRID 1030389 reaction equation
C([O:5][C:6]([CH2:8][O:9][C:10]1[C:11]([CH3:47])=[C:12]2[C:17](=[C:18]([CH3:21])[C:19]=1[CH3:20])[O:16][C:15]([CH2:23][O:24][C:25]1[CH:46]=[CH:45][C:28]([CH2:29][CH:30]3[S:34][C:33](=[O:35])[N:32]([CH2:36][C:37]([O:39]C(C)(C)C)=[O:38])[C:31]3=[O:44])=[CH:27][CH:26]=1)([CH3:22])[CH2:14][CH2:13]2)=[O:7])(C)(C)C.Cl>O1CCOCC1>[C:6]([CH2:8][O:9][C:10]1[C:11]([CH3:47])=[C:12]2[C:17](=[C:18]([CH3:21])[C:19]=1[CH3:20])[O:16][C:15]([CH2:23][O:24][C:25]1[CH:46]=[CH:45][C:28]([CH2:29][CH:30]3[S:34][C:33](=[O:35])[N:32]([CH2:36][C:37]([OH:39])=[O:38])[C:31]3=[O:44])=[CH:27][CH:26]=1)([CH3:22])[CH2:14][CH2:13]2)([OH:7])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19822207HCID 19822207, compound

Product 1

HCID 19822201HCID 19822201, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 0.63 g of t-butyl α-{5-[4-(6-t-butoxycarbonylmethoxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]-2,4-dioxothiazolidin-3-yl}acetate (prepared as described in Example 48) and 6 ml of a 4N dioxane solution of hydrogen chloride was allowed to stand at room temperature overnight. At the end of this time, the reaction mixture was treated as the same manner described in Example 61, to give the title compound as a pale yellow powder, softening at 95°-100° C.

Workup

  1. additionAt the end of this time, the reaction mixture was treated as the same manner

Sources & evidence

ORD record
ord-21230f54d33c40338fbe4d435572456d
Source dataset
uspto-grants-1992_04
Patent number
US05104888

Reaction notes

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