Hydrochloric Acid → HCID 19822256, compound

HRID 1030416Notes

Reaction equation

HRID 1030416 reaction equation
[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[C:15]([CH3:18])([CH3:17])[CH3:16])[O:11][C:10]([CH2:20][O:21][C:22]1[CH:27]=[C:26](N)[CH:25]=[CH:24][C:23]=1[CH3:29])([CH3:19])[CH2:9][C:8]2=[O:30])(=[O:3])[CH3:2].N([O-])=O.[Na+].[ClH:35].[C:36]([O:40][CH2:41][CH3:42])(=[O:39])[CH:37]=[CH2:38]>CC(C)=O>[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[C:15]([CH3:18])([CH3:17])[CH3:16])[O:11][C:10]([CH2:20][O:21][C:22]1[CH:27]=[C:26]([CH2:38][CH:37]([Cl:35])[C:36]([O:40][CH2:41][CH3:42])=[O:39])[CH:25]=[CH:24][C:23]=1[CH3:29])([CH3:19])[CH2:9][C:8]2=[O:30])(=[O:3])[CH3:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8821Ethyl AcrylateHCID 19822224HCID 19822224, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 19822256HCID 19822256, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Following the same procedure as described in Preparation 25, 5.53 g of 6-acetoxy-2-(5-amino-2-methylphenoxymethyl)-7-t-butyl-2-methylchroman-4-one (prepared as described in Preparation 41), 1.2 g of sodium nitrite, 2.4 ml of concentrated hydrochloric acid, 14 ml of ethyl acrylate, 190 ml of cuprous oxide and 50 ml of acetone were reacted, to give the title compound as a pale yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-62a3016950a843ffad799771de59dde2
Source dataset
uspto-grants-1992_04
Patent number
US05104888

Reaction notes

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