Hydrochloric Acid → HCID 19822265, compound

HRID 1030428Notes

Reaction equation

HRID 1030428 reaction equation
[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[C:15]([CH3:18])([CH3:17])[CH3:16])[O:11][C:10]([CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25](N)=[CH:24][CH:23]=1)([CH3:19])[CH2:9][CH2:8]2)(=[O:3])[CH3:2].N([O-])=O.[Na+].[ClH:33].[C:34]([O:38][CH2:39][CH3:40])(=[O:37])[CH:35]=[CH2:36]>CC(C)=O>[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[C:15]([CH3:18])([CH3:17])[CH3:16])[O:11][C:10]([CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:36][CH:35]([Cl:33])[C:34]([O:38][CH2:39][CH3:40])=[O:37])=[CH:24][CH:23]=1)([CH3:19])[CH2:9][CH2:8]2)(=[O:3])[CH3:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8821Ethyl AcrylateHCID 19822172HCID 19822172, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 19822265HCID 19822265, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Following the procedure described in Preparation 51, 1.74 g of 6-acetoxy-2-(4-aminophenoxymethyl)-7-t-butyl-2-methylchroman (prepared as described in Preparation 58), 380 mg of sodium nitrite, 0.8 ml of concentrated hydrochloric acid, 4.5 g of ethyl acrylate, 65 mg of cuprous oxide and 17 ml of acetone were reacted, to give the title compound as a slightly yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-959fcc4db8794194962bcc3995adc4a1
Source dataset
uspto-grants-1992_04
Patent number
US05104888

Reaction notes

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