Urea → HCID 287116, compound

HRID 1030487Notes

Reaction equation

HRID 1030487 reaction equation
[Na].[NH2:2][C:3]([NH2:5])=[O:4].C([C:8]1[C:9]([C:14](O)=[O:15])=[N:10][CH:11]=[CH:12][CH:13]=1)C>N>[N:10]1[CH:11]=[CH:12][CH:13]=[CH:8][C:9]=1[C:14]([NH:2][C:3]([NH2:5])=[O:4])=[O:15]

Participants

5

Reactant 3

HCID 1176UreaHCID 5360545SodiumHCID 178418573-Ethylpyridine-2-carboxylic acid

Product 1

HCID 287116HCID 287116, compound

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

A mixture of sodium (0.23 g, 10 mmol), urea (0.8 g, 13.3 mmol) and liquid ammonia (40 ml) was stirred until the blue colour was discharged, then ethyl 2-pyridinecarboxylic acid (2.85 g, 18.8 mmol) was added all at once. After 1 h the ammonia was evaporated and the residue triturated with water to give the above compound, mp 183°-185° C.

Workup

  1. customAfter 1 h the ammonia was evaporated
  2. customthe residue triturated with water
  3. customto give the above compound, mp 183°-185° C.

Sources & evidence

ORD record
ord-0591ab8b2b0e4db19558bbc12e1f6b05
Source dataset
uspto-grants-1992_04
Patent number
US05106843

Reaction notes

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