反应详情

温度

40 °C

85% Hydrazine hydrate (1.67 ml) was added to a suspension of N-(5-fluoro-2-nitrophenyl)methyl-phthalimide (7.1 g) in ethanol (90 ml). The reaction mixture was heated to reflux for 3 hours, then cooled to 40° C. Hydrochloric acid was added and stirring was continued at that temperature for a further hour; then the solvent was removed under vacuum. The residue was taken up in water and the solid which separated was discarded. The mother liquors were treated with 10% sodium hydroxide and extracted with diethyl ether. After evaporation of the solvent 3.5 g of title compound were obtained as a reddish oil.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 3 hours
3. waitwas continued at that temperature for a further hour
4. customthen the solvent was removed under vacuum
5. customthe solid which separated
6. additionThe mother liquors were treated with 10% sodium hydroxide
7. extractionextracted with diethyl ether
8. customAfter evaporation of the solvent 3.5 g of title compound
9. customwere obtained as a reddish oil