Hydrochloric Acid → HCID 18755231, compound

HRID 1030569Notes

Reaction equation

HRID 1030569 reaction equation
[ClH:1].[CH3:2][N:3]1[C:7](=[O:8])[C@@H:6]([CH3:9])[S:5][C@H:4]1[C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1>C(O)C>[ClH:1].[CH3:2][N:3]1[C:7](=[O:8])[CH:6]([CH3:9])[S:5][CH:4]1[C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 122326HCID 122326, compound

Product 1

HCID 18755231HCID 18755231, compoundYield 86.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
0 °C

Procedure

Conc. aqueous HCl (4.75 g, 45.6 mmol) was added dropwise to a solution of cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one (10 g, 48 mmol) from Example 2 in ethanol (50 ml) at room temperature. Then the mixture was cooled to 0° C., and the precipitated crystals were filtered and the title compound (9.621 g, 86.28 yield) was obtained. m.p. 190°-193° C.

Workup

  1. filtrationthe precipitated crystals were filtered

Sources & evidence

ORD record
ord-c11089aafb5744278a0fa33cccad822b
Source dataset
uspto-grants-1992_04
Patent number
US05106860

Reaction notes

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