Hydrochloric Acid → HCID 131717311, compound

HRID 1030651Notes

Reaction equation

HRID 1030651 reaction equation
C(OC[C:5]([CH2:27]OCC)([OH:26])[CH:6]([NH:18]C(OC(C)(C)C)=O)[CH2:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[C:10]([O:16][CH3:17])[CH:9]=1)C.[ClH:31]>>[ClH:31].[NH2:18][CH:6]1[CH2:7][C:8]2[C:9](=[C:10]([O:16][CH3:17])[CH:11]=[C:12]([O:14][CH3:15])[CH:13]=2)[CH2:27][C:5]1=[O:26]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19820684HCID 19820684, compound

Product 1

HCID 131717311HCID 131717311, compound

Conditions

Temperature
0 °C

Procedure

α,α-Diethoxymethyl-β-tert-butoxycarbonylamino-3,5-dimethoxy-benzenepropanol (200 g) was dissolved in aqueous 37% hydrochloric acid (20 ml) cooled at 0° C. The resulting red solution was warmed at 100° C. for 3 minutes and then immediate ly cooled at 0° C. Evaporation of the reaction mixture yielded a brown solid which was recrystallized from an ethyl acetate/methanol mixture to give the title compound as a brown solid (101 mg).

Workup

  1. temperatureThe resulting red solution was warmed at 100° C. for 3 minutes
  2. temperatureimmediate ly cooled at 0° C
  3. customEvaporation of the reaction mixture
  4. customyielded a brown solid which
  5. customwas recrystallized from an ethyl acetate/methanol mixture

Sources & evidence

ORD record
ord-0c21f2959f8c4eeb9f935f9a89892c15
Source dataset
uspto-grants-1992_04
Patent number
US05106861

Reaction notes

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