反应详情

In 15 ml of anhydrous tetrahydrofuran was dissolved 3.0 g of 2',4',6'-trihydroxyacetophenone, and 7.4 g of anhydrous potassium carbonate was added to the solution and the mixture was stirred at room temperature for 30 minutes. Then, 2.5 g of 3-bromo-1-propene was added to the mixture and reaction was carried out at room temperature for 3 hours. After the reaction, the reaction mixture was extracted with 500 ml of diethyl ether, and the solvent was removed from the extract by distillation. The obtained residue was recrystallized from benzene to obtain 1.5 g (yield=41.5%) of 2',4',6'-trihydroxy-3'-(2-propenyl)acetophenone in the form of a colorless prism.

1. additionwas added to the solution
2. waitwas carried out at room temperature for 3 hours
3. customAfter the reaction
4. extractionthe reaction mixture was extracted with 500 ml of diethyl ether
5. customthe solvent was removed from the
6. extractionextract by distillation
7. customThe obtained residue was recrystallized from benzene