反应详情

A solution of 30 g of ethyl formamido-malonate in 300 ml of acetonitrile was added to a mixture of 40 g of potassium carbonate, 0.380 g of 18 crown 6 ether catalyst and 39.9 g of chloromethylpropane and the mixture was refluxed for 3 hours and then filtered. The filtrate was dried and cooled to 0° to 5° C. The precipitate was taken up in isopropyl ether and filtered. The product was washed with isopropyl ether and was dried under reduced pressure to obtain 25.2 g of the desired product melting at 72° C.

1. temperaturethe mixture was refluxed for 3 hours
2. filtrationfiltered
3. customThe filtrate was dried
4. temperaturecooled to 0° to 5° C
5. filtrationfiltered
6. washThe product was washed with isopropyl ether
7. customwas dried under reduced pressure