P-Anisidine → 4-Acetyl-N-(4-methoxyphenyl)benzenesulfonamide

HRID 1031298Notes

Reaction equation

HRID 1031298 reaction equation
CC(=O)c1ccc(S(=O)(=O)Cl)cc1.COc1ccc(N)cc1>CC(C)=O.O.O=C([O-])O.OCCOCCOCCOCCOCCO.[Na+]>COc1ccc(NS(=O)(=O)c2ccc(C(C)=O)cc2)cc1

Participants

7

Reactant 2

HCID 7732P-AnisidineHCID 2664184-Acetylbenzenesulfonyl chloride

Product 1

HCID 20640474-Acetyl-N-(4-methoxyphenyl)benzenesulfonamideYield 100%

Reagents, catalysts & solvents 4

HCID 516892Sodium BicarbonateReagentHCID 180AcetoneSolventHCID 962WaterSolventHCID 62551Pentaethylene glycolSolvent

Conditions

Temperature
25 °C

Workup

  1. additionNo procedure recorded
  2. extractionKeep organic
  3. washNo procedure recorded
  4. washNo procedure recorded
  5. dry with materialNo procedure recorded
  6. concentrationNo procedure recorded

Sources & evidence

ORD record
ord-64b2625cf0d0437d98111a403df2197f
Source dataset
39 compound library from "Building a Sulfonamide Library by Eco-Friendly Flow Synthesis"
Original link
View source

Reaction notes

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