2-Mesitylenesulfonyl chloride → 1-(2,4,6-trimethylphenyl)sulfonyl-3,4-dihydro-2H-quinoline

HRID 1031314Notes

Reaction equation

HRID 1031314 reaction equation
Cc1cc(C)c(S(=O)(=O)Cl)c(C)c1.c1ccc2c(c1)CCCN2>CC(C)=O.O.O=C([O-])O.OCCOCCOCCOCCOCCO.[Na+]>Cc1cc(C)c(S(=O)(=O)N2CCCc3ccccc32)c(C)c1

Participants

7

Reactant 2

HCID 130462-Mesitylenesulfonyl chlorideHCID 694601,2,3,4-Tetrahydroquinoline

Product 1

HCID 6690931-(2,4,6-trimethylphenyl)sulfonyl-3,4-dihydro-2H-quinolineYield 86%

Reagents, catalysts & solvents 4

HCID 516892Sodium BicarbonateReagentHCID 180AcetoneSolventHCID 962WaterSolventHCID 62551Pentaethylene glycolSolvent

Conditions

Temperature
25 °C

Workup

  1. additionNo procedure recorded
  2. extractionKeep organic
  3. washNo procedure recorded
  4. washNo procedure recorded
  5. dry with materialNo procedure recorded
  6. concentrationNo procedure recorded

Sources & evidence

ORD record
ord-05d160f1b7da441183b9fa501f445612
Source dataset
39 compound library from "Building a Sulfonamide Library by Eco-Friendly Flow Synthesis"
Original link
View source

Reaction notes

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