反应详情

To a solution of a benzoylhydrazinecarboxylic acid tert-butyl ester (Example 7) in acetic acid (5 mL) is added N-chlorosuccinimide (1.2 eq.). After 1 hour, the reaction mixture is diluted with ethyl acetate and washed with saturated NaHCO3, water, and brine. The organic layer is dried over MgSO4 and filtered. The filtrate is concentrated under vacuum and purified via flash column chromatography (ethyl acetate/hexanes) to afford the corresponding chloro-benzoylhydrazinecarboxylic acid tert-butyl ester.

1. washwashed with saturated NaHCO3, water, and brine
2. dry with materialThe organic layer is dried over MgSO4
3. filtrationfiltered
4. concentrationThe filtrate is concentrated under vacuum
5. custompurified via flash column chromatography (ethyl acetate/hexanes)