Triethylamine → HCID 22168011, compound

HRID 1031612Notes

Reaction equation

HRID 1031612 reaction equation
Br.Br.[N:3]1([CH2:8][CH:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][C:17]=3[OH:19])[CH2:12][CH2:11][NH:10]2)[CH2:7][CH2:6][CH2:5][CH2:4]1.Br.Br.N1(CC2C3C(=CC(O)=CC=3)CCN2)CCCC1.[Cl:39][C:40]1[CH:41]=[C:42]([CH2:47][C:48](O)=[O:49])[CH:43]=[CH:44][C:45]=1[Cl:46].C(N(CC)CC)C.C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)(Cl)Cl>[N:3]1([CH2:8][C:9]2([C:48](=[O:49])[CH2:47][C:42]3[CH:43]=[CH:44][C:45]([Cl:46])=[C:40]([Cl:39])[CH:41]=3)[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][C:17]=3[OH:19])[CH2:12][CH2:11][NH:10]2)[CH2:7][CH2:6][CH2:5][CH2:4]1

Participants

7

Reactant 5

HCID 8471TriethylamineHCID 10868DicyclohexylcarbodiimideHCID 798743,4-Dichlorophenylacetic acidHCID 22168045HCID 22168045, compoundHCID 22168074HCID 22168074, compound

Product 1

HCID 22168011HCID 22168011, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared as Ex. No. 5, from 13.2 g (33.50 mmoles) of a mixture containing 1-(pyrrolidin-1-yl)methyl-8-hydroxy-1,2,3,4-tetrahydroisoquinoline dihydrobromide and 1-(pyrrolidin-1-yl)methyl-6-hydroxy-1,2,3,4-tetrahydroisoquinoline dihydrobromide, 9.6 g (46.8 mmoles) of 3,4-dichlorophenylacetic acid, 14 ml (99.6 mmoles) of triethylamine and 17 g (82.52 mmoles) of dicyclohexylcarbodiimide, in 280 ml of dry chloroform.

Workup

  1. customPrepared as Ex

Sources & evidence

ORD record
ord-e1d936a93b404b44b7d7897a233d757b
Source dataset
uspto-grants-1990_09
Patent number
US04954509

Reaction notes

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