Gamma-Butyrolactone → HCID 19048438, compound

HRID 1031836Notes

Reaction equation

HRID 1031836 reaction equation
Cl.[NH2:2][CH2:3][CH2:4][SH:5].N(CCO)(CCO)CCO.[C:16]1(=[O:21])[O:20][CH2:19][CH2:18][CH2:17]1>>[OH:21][CH2:16][CH2:17][CH2:18][C:19]([NH:2][CH2:3][CH2:4][SH:5])=[O:20]

Participants

4

Reactant 3

HCID 7302Gamma-Butyrolactone2×HCID 7618TriethanolamineHCID 9082Cysteamine Hydrochloride

Product 1

HCID 19048438HCID 19048438, compound

Procedure

In a reactor there are introduced, at ambient temperature and under an inert atmosphere, 11.4 g of cysteamine hydrochloride and then slowly, with stirring, 13.5 cm3 of triethanolamine. To the resulting mixture, brought to a temperature of about 60° C., 7.7 cm3 of γ-butyrolactone are slowly added. At the end of the introduction the whole is brought to a temperature of 90° C. for three hours, at the end of which time all the γ-butyrolactone is transformed (VPC verification). 32 g of 4-hydroxy N-(2-mercaptoethyl) butyramide are obtained containing one equivalent of triethanolamine hydrochloride in the form of a pasty white solid that is conditioned under an inert atmosphere.

Workup

  1. additionare slowly added

Sources & evidence

ORD record
ord-3bbcc8431f8c4355a215d9ac77518551
Source dataset
uspto-grants-1990_09
Patent number
US04956175

Reaction notes

Loading…