反应详情

A mixture of 5-butoxy-4-hydroxy-2-nitrobenzaldehyde (31 g; 0.13 mole), benzylchloride (20.2 g; 0.16 mole) and potassium carbonate (22.11 g; 0.16 mole) in 80 ml of dimethylformamide is heated for 2 hours under reflux with stirring. The reaction mixture is poured into 200 ml of ice-cold water and the precipitate filtered off. After recrystallization in a hexane/toluene mixture, 4-benzyloxy-5-butoxy-2-nitrobenzaldehyde (30.2 g; 71% yield; yellow powder) is obtained; melting point 94° C.

1. temperatureis heated for 2 hours
2. temperatureunder reflux
3. filtrationthe precipitate filtered off
4. customAfter recrystallization in a hexane/toluene mixture