反应详情

A mixture of 3-[2-(1,5-diphenyl-1H-pyrazol-3-yl)ethyl]phenol (4.50 g, 13 mmol), methyl bromoacetate (2.23 g, 1.375 mL, 14.5 mmol), potassium carbonate (2.19 g, 16 mmol), potassium iodide (catalytic amount) and acetonitrile (80 mL) was stirred at reflux for 3 hours. The mixture was filtered, concentrated and the residue chromatographed on a column of silica gel prepared in a mixture of hexanes and diethyl ether (9:1). Subsequent elution with a mixture of hexanes and diethyl ether (1:1) furnished methyl [3-[2-(1,5-diphenyl-1H-pyrazol-3-yl)ethyl]phenoxy]acetate (4.83 g, 85% ) as an oil.

1. temperatureat reflux for 3 hours
2. filtrationThe mixture was filtered
3. concentrationconcentrated
4. customthe residue chromatographed on a column of silica gel
5. customprepared in a mixture of hexanes and diethyl ether (9:1)
6. washSubsequent elution
7. additionwith a mixture of hexanes and diethyl ether (1:1)