HCID 14422913, compound → 1-Cyclopropyl-6,8-difluoro-7-methyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

HRID 1032018Notes

Reaction equation

HRID 1032018 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:19])=[C:11]([CH2:15]C(O)=O)[C:12]=3[F:14])[C:7](=[O:20])[C:6]([C:21]([OH:23])=[O:22])=[CH:5]2)[CH2:3][CH2:2]1>C1(OC2C=CC=CC=2)C=CC=CC=1>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:19])=[C:11]([CH3:15])[C:12]=3[F:14])[C:7](=[O:20])[C:6]([C:21]([OH:23])=[O:22])=[CH:5]2)[CH2:2][CH2:3]1

Participants

3

Reactant 1

HCID 14422913HCID 14422913, compound

Product 1

HCID 136574231-Cyclopropyl-6,8-difluoro-7-methyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

0.5 g of the compound from Example 11 is heated to 240° C. for one hour in 5 ml of diphenyl ether. The residue remaining after distilling off the solvent consists of 0.3 g of crude product of melting point 208°-10° C. Recrystallization from ethanol gives a melting point of 226°-28°.

Workup

  1. distillationafter distilling off the solvent
  2. customRecrystallization from ethanol
  3. customgives a melting point of 226°-28°

Sources & evidence

ORD record
ord-1d37e95ba85d4073845ff7bcabf66e34
Source dataset
uspto-grants-1990_09
Patent number
US04956465

Reaction notes

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