Potassium Carbonate → HCID 14556315, compound

HRID 1032340Notes

Reaction equation

HRID 1032340 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[O:9][CH2:10][CH2:11]Br)=[CH:4][CH:3]=1.[CH:20]([O:23][C:24]1[CH:25]=[C:26]([CH:30]2[CH2:34][CH2:33][NH:32][CH2:31]2)[CH:27]=[CH:28][CH:29]=1)([CH3:22])[CH3:21].C(=O)([O-])[O-].[K+].[K+]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[O:9][CH2:10][CH2:11][N:32]2[CH2:33][CH2:34][CH:30]([C:26]3[CH:27]=[CH:28][CH:29]=[C:24]([O:23][CH:20]([CH3:22])[CH3:21])[CH:25]=3)[CH2:31]2)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 105681861-Bromo-2-[bis(4-fluorophenyl)methoxy]ethaneHCID 14556324HCID 14556324, compound

Product 1

HCID 14556315HCID 14556315, compoundYield 73%

Procedure

Proceeding as in Example 9, using 16.4 g (50 mmole) of 1-[bis(4-fluorophenyl)methoxy]-2-bromoethane, 10.3 g (50 mmole) of 3-(3-1isopropoxyphenyl)pyrrolidine and 13.8 g (100 mmole) of potassium carbonate, there was obtained after silica gel column filtration, 16.4 g (yield: 73%) of 1-[2-[bis(4-fluorophenyl) methoxy]ethyl]-3-(3-isopropoxyphenyl)pyrrolidine.

Workup

  1. customthere was obtained

Sources & evidence

ORD record
ord-3ba46551880346929a4ba720c50f4b79
Source dataset
uspto-grants-1990_09
Patent number
US04957927

Reaction notes

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