Potassium Carbonate → HCID 14556316, compound

HRID 1032341Notes

Reaction equation

HRID 1032341 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[O:9][CH2:10][CH2:11]Br)=[CH:4][CH:3]=1.[CH3:20][O:21][C:22]1[CH:23]=[C:24]([CH:30]2[CH2:34][CH2:33][NH:32][CH2:31]2)[CH:25]=[C:26]([O:28][CH3:29])[CH:27]=1.C(=O)([O-])[O-].[K+].[K+]>C(Cl)(Cl)Cl.CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[O:9][CH2:10][CH2:11][N:32]2[CH2:33][CH2:34][CH:30]([C:24]3[CH:25]=[C:26]([O:28][CH3:29])[CH:27]=[C:22]([O:21][CH3:20])[CH:23]=3)[CH2:31]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 105681861-Bromo-2-[bis(4-fluorophenyl)methoxy]ethaneHCID 14556325129084-50-0

Product 1

HCID 14556316HCID 14556316, compoundYield 46.5%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

Proceeding as in Example 9, using 14.8 g (45 mmole) of 1-[bis(4-fluorophenyl)methoxy]-2-bromoethane, 9.4 g (45 mmole) of 3-(3,5-dimethoxyphenyl)pyrrolidine and 12 g (86 mmole) of potassium carbonate, there was obtained after silica gel column chromatography (eluent chloroform-methanol, 9/1), 9.5 g (yield: 46%) of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-3-(3,5-dimethoxy phenyl)pyrrolidine.

Sources & evidence

ORD record
ord-ff9f2269694b4e90bb6a06c0516b061b
Source dataset
uspto-grants-1990_09
Patent number
US04957927

Reaction notes

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