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HRID1032341

反应详情

EQUATION

反应方程式

HRID 1032341 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：Fc1ccc(C(OCCBr)c2ccc(F)cc2)cc1
HCID10568186

Benzene, 1,1'-[(2-bromoethoxy)methylene]bis[4-fluoro-

C15H13BrF2O

结构：COc1cc(OC)cc(C2CCNC2)c1
HCID14556325

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc(OC)cc(C2CCN(CCOC(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1
HCID14556316

未命名化合物

收率 46.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO.ClC(Cl)Cl
溶剂HCID21584188

Chloroform methanol

C2H5Cl3O

PROCEDURE

实验过程

Proceeding as in Example 9, using 14.8 g (45 mmole) of 1-[bis(4-fluorophenyl)methoxy]-2-bromoethane, 9.4 g (45 mmole) of 3-(3,5-dimethoxyphenyl)pyrrolidine and 12 g (86 mmole) of potassium carbonate, there was obtained after silica gel column chromatography (eluent chloroform-methanol, 9/1), 9.5 g (yield: 46%) of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-3-(3,5-dimethoxy phenyl)pyrrolidine.