Ammonia → HCID 19759073, compound

HRID 1032380Notes

Reaction equation

HRID 1032380 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([C:12]2[N:17]=[CH:16][CH:15]=[CH:14][N:13]=2)(=[O:11])=[O:10])=[CH:5][CH:4]=1.Br.N>>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([C:12]2[N:13]=[CH:14][CH:15]=[CH:16][N:17]=2)(=[O:11])=[O:10])=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 260Hydrogen BromideHCID 197590592-(4-Methoxybenzene-1-sulfonyl)pyrimidine

Product 1

HCID 19759073HCID 19759073, compound

Conditions

Temperature
90 °C

Procedure

A mixture of 4.6×10-3 mol of 2-(4-methoxybenzenesulphonyl)pyrimidine and 10 of 47%-hydrobromic acid was heated for - hour at 90° C. The reaction medium was neutralized to a pH of 7 with an ammonia solution and the pasty residue was extracted with dichloromethane. The organic phase was then dried and evaporated and the residue so provided was purified by chromatography on a silica column using dichloromethane as eluent.

Workup

  1. extractionthe pasty residue was extracted with dichloromethane
  2. customThe organic phase was then dried
  3. customevaporated
  4. customthe residue so provided
  5. customwas purified by chromatography on a silica column

Sources & evidence

ORD record
ord-28ae75e14d254552a6ecdbc189c54ae3
Source dataset
uspto-grants-1990_09
Patent number
US04957925

Reaction notes

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