HCID 131716564, compound → HCID 67907421, compound

HRID 1032445Notes

Reaction equation

HRID 1032445 reaction equation
C([O:3][C:4](=[O:37])[CH2:5][C@H:6]1[CH2:11][C@@H:10]([CH:12]=[CH:13][C:14]2[C:15]([CH:32]([CH3:34])[CH3:33])=[N:16][N:17]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=3)[C:18]=2[C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)[O:9]C(C)(C)[O:7]1)C.[H][H]>C(OCC)(=O)C.[Pd]>[F:25][C:22]1[CH:23]=[CH:24][C:19]([C:18]2[N:17]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=3)[N:16]=[C:15]([CH:32]([CH3:34])[CH3:33])[C:14]=2[CH:13]=[CH:12][CH:10]([OH:9])[CH2:11][CH:6]([OH:7])[CH2:5][C:4]([OH:37])=[O:3])=[CH:20][CH:21]=1

Participants

5

Reactant 2

HCID 131716564HCID 131716564, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67907421HCID 67907421, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 1.44 g (2.84 mmol) of cis-(±)-ethyl-6-[2[5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H- pyrazol-4-yl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate in 15 ml of ethyl acetate was catalytically reduced under one atmosphere of hydrogen gas in the presence of 20% Pd/C. at 25° C. for four days.

Sources & evidence

ORD record
ord-9a54964b0f8a405a98ae0b89176deaa0
Source dataset
uspto-grants-1990_09
Patent number
US04957971

Reaction notes

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