Sodium Cyanide → (4-Benzyloxy-3-nitrophenyl)acetonitrile

HRID 1032514노트

반응식

HRID 1032514 반응식
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13]Cl)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C-:20]#[N:21].[Na+]>CS(C)=O>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][C:20]#[N:21])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 8929Sodium CyanideHCID 136293024-Benzyloxy-3-nitrobenzyl chloride

생성물 1

HCID 13629303(4-Benzyloxy-3-nitrophenyl)acetonitrile수율 88.6%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

111.0 g of 4-benzyloxy-3-nitrobenzyl chloride and 21.6 g of sodium cyanide in 800 ml of dimethyl sulfoxide are stirred for 2.5 hours at 40° C., then poured into 1.6 1 of ice water. The solid product is recrystallized from ethanol, yielding 95.0 g of (4-benzyloxy-3-nitrophenyl)acetonitrile, mp 91°-97° C.

후처리

  1. customThe solid product is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-190d917ec37c47c98b3d83ba90d14b2b
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04958026

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