Methyl iodide → HCID 178470072, compound

HRID 1032734Notes

Reaction equation

HRID 1032734 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)[CH:11]=2)[C:6](=[O:19])[C:5]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[C:4]1[OH:25])C.C(N1C2C(=CC=C(C3C=NC=CC=3)C=2)C(=O)C(C(O)=O)=C1)C.[H-].[Na+].CI>>[OH:25][C:4]1[N:3]([CH3:1])[C:12]2[C:7]([C:6](=[O:19])[C:5]=1[C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:8][CH:9]=[C:10]([C:13]1[CH:14]=[CH:15][N:16]=[CH:17][CH:18]=1)[CH:11]=2

Participants

5

Reactant 4

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 104471501-Ethyl-1,4-dihydro-4-oxo-7-(3-pyridinyl)-3-quinolinecarboxylic acidHCID 178470078HCID 178470078, compound

Product 1

HCID 178470072HCID 178470072, compound

Procedure

Ethyl 1,4-dihydro-2-hydroxy-1-methyl-4-oxo-7-(4-pyridinyl)-3-quinolinecarboxylate was prepared from 7.20 g dioxobenzoxazine of Example 38, part (a), 1.66 g 60% sodium hydride and 1.95 ml methyl iodide according to the procedure of Example 38, part (b), and was obtained (4.50 g) as a yellow solid, m.p. about 184° C(decompn.).

Workup

  1. customwas obtained (4.50 g) as a yellow solid, m.p. about 184° C(decompn.)

Sources & evidence

ORD record
ord-80e0f111516e420bb86cf3aadae7756f
Source dataset
uspto-grants-1990_09
Patent number
US04959363

Reaction notes

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