反应详情

温度

90 °C

A mixture of 18.6 g of methyl 5-chlorosalicylate, 28 g of K2CO3 and 20 g of 3-bromocyclohexene in 200 ml of DMF is stirred at 90° C. overnight. The mixture is then poured onto water, extracted with ethylacetate, washed with water, dried over magnesium sulfate and evaporated to dryness to obtain crude product. This is purified by flash chromatography using hexane as the eluent to give pure methyl 2-(cyclohexen-3-yloxy)-5-chlorobenzoate as the first fraction which is used directly in the next step.

1. additionThe mixture is then poured onto water
2. extractionextracted with ethylacetate
3. washwashed with water
4. dry with materialdried over magnesium sulfate
5. customevaporated to dryness
6. customto obtain crude product
7. customThis is purified by flash chromatography