Hydrochloric Acid → HCID 15704187, compound

HRID 1033046Notes

Reaction equation

HRID 1033046 reaction equation
[O-:1][C:2]#[N:3].[K+].[NH2:5][CH2:6][C:7]1[O:11][C:10]([C:12]2[N:13]=[C:14]([NH:17][C:18]([NH2:20])=[S:19])[S:15][CH:16]=2)=[CH:9][CH:8]=1.Cl>O.CN(C)C=O>[NH:17]([C:14]1[S:15][CH:16]=[C:12]([C:10]2[O:11][C:7]([CH2:6][NH:5][C:2]([NH2:3])=[O:1])=[CH:8][CH:9]=2)[N:13]=1)[C:18]([NH2:20])=[S:19]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 11378442Potassium cyanateHCID 15704186HCID 15704186, compound

Product 1

HCID 15704187HCID 15704187, compoundYield 91.9%

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 6228DimethylformamideSolvent

Procedure

A solution of potassium cyanate (9.6 g) in water (50 ml) was added to a mixture of 4-(5-aminomethylfuran-2-yl)-2-thioureidothiazole (10.0 g) in N,N-dimethylformamide (80 ml) and 1N-hydrochloric acid (78.6 ml), and the mixture was stirred for 16 hours at ambient temperature. To the reaction mixture was added a water (100 ml) and isolated precipitate was collected by filtration to give 2-thioureido-4-(5-ureidomethylfuran-2-yl)thiazole (10.74 g).

Workup

  1. customisolated precipitate
  2. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-7abe8b8e1c6c4958ab436cebc2da7773
Source dataset
uspto-grants-1994_05
Patent number
US05308857

Reaction notes

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