Methyl iodide → HCID 86747809, compound

HRID 1033047Notes

Reaction equation

HRID 1033047 reaction equation
[C:1]([CH2:3][C:4]1[O:8][C:7]([C:9]2[N:10]=[C:11]([NH:14][C:15]([NH2:17])=[S:16])[S:12][CH:13]=2)=[CH:6][CH:5]=1)#[N:2].[CH3:18][I:19]>CO.O1CCCC1>[IH:19].[NH2:17][C:15](=[N:14][C:11]1[S:12][CH:13]=[C:9]([C:7]2[O:8][C:4]([CH2:3][C:1]#[N:2])=[CH:5][CH:6]=2)[N:10]=1)[S:16][CH3:18]

Participants

5

Reactant 2

HCID 6328Methyl iodideHCID 15704184HCID 15704184, compound

Product 1

HCID 86747809HCID 86747809, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 4-(5-cyanomethylfuran-2-yl)-2-thioureidothiazole (11.4 g) and methyl iodide (2.7 ml) in methanol (110 ml) and tetrahydrofuran (60 ml) was refluxed for 1.5 hours under stirring. Evaporation of the solvent gave a residue, which was triturated with ethyl acetate to give 2-[(amino)(methylthio)methyleneamino]-4-(5-cyanomethylfuran-2-yl)thiazole hydriodide (14.50 g).

Workup

  1. temperaturewas refluxed for 1.5 hours
  2. customEvaporation of the solvent
  3. customgave a residue, which
  4. customwas triturated with ethyl acetate

Sources & evidence

ORD record
ord-06a356bb4149477585eb102287a285a6
Source dataset
uspto-grants-1994_05
Patent number
US05308857

Reaction notes

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