Hydrochloric Acid → HCID 67826748, compound

HRID 1033086Notes

Reaction equation

HRID 1033086 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH:5]1[S:10](=[O:12])(=[O:11])[C:9]2[S:13][C:14]([S:16]([NH2:19])(=[O:18])=[O:17])=[CH:15][C:8]=2[CH:7]([NH:20]C(=O)CC)[CH2:6]1.Cl>CO>[NH2:20][CH:7]1[CH2:6][CH:5]([CH2:4][CH2:3][CH2:2][OH:1])[S:10](=[O:12])(=[O:11])[C:9]2[S:13][C:14]([S:16]([NH2:19])(=[O:18])=[O:17])=[CH:15][C:8]1=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67826411HCID 67826411, compound

Product 1

HCID 67826748HCID 67826748, compoundYield 5.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of compound from Step A (100 mg., 0.42 mM) CH3OH (25 ml.) and 12N HCl (3 ml.) was heated at reflux for 24 hours. The CH3OH was evaporated in vacuo. The aqueous phase was made basic with saturated sodium carbonate, evaporated to dryness and extracted with hot ethyl acetate which was evaporated to dryness to give 5 mg of title compound.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 24 hours
  3. customThe CH3OH was evaporated in vacuo
  4. customevaporated to dryness
  5. extractionextracted with hot ethyl acetate which
  6. customwas evaporated to dryness

Sources & evidence

ORD record
ord-fb6d694a3f94478a8e53143200920eb9
Source dataset
uspto-grants-1994_05
Patent number
US05308863

Reaction notes

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