Hydrochloric Acid → HCID 86747819, compound

HRID 1033125Notes

Reaction equation

HRID 1033125 reaction equation
Cl.[CH2:2]([C:6]1[N:7]([CH2:26][C:27]2[CH:36]=[CH:35][C:30]([C:31]([O:33][CH3:34])=[O:32])=[CH:29][CH:28]=2)[C:8](/[CH:11]=[C:12]2\[N:13]([CH2:22][CH2:23][CH2:24][CH3:25])[C:14](=[O:21])[N:15]([CH2:18][O:19][CH3:20])[C:16]\2=[O:17])=[CH:9][N:10]=1)[CH2:3][CH2:4][CH3:5].[OH-:37].[Na+].CO.Cl>C1COCC1>[CH2:2]([C:6]1[N:7]([CH2:26][C:27]2[CH:28]=[CH:29][C:30]([C:31]([O:33][CH3:34])=[O:32])=[CH:35][CH:36]=2)[C:8](/[CH:11]=[C:12](\[N:13]([CH2:22][CH2:23][CH2:24][CH3:25])[C:14]([NH:15][CH2:18][O:19][CH3:20])=[O:21])/[C:16]([OH:17])=[O:37])=[CH:9][N:10]=1)[CH2:3][CH2:4][CH3:5]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 19919852HCID 19919852, compound

Product 1

HCID 86747819HCID 86747819, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of methyl Z-4-[[2-butyl-5-[[3-butyl-1-(methoxymethyl)-2,5-dioxo-4-imidazolidinylidene]methyl]-1H-imidazol-1-yl]methyl]benzoate monohydrochlorde. (0.100 g, 0.193 mmol) in THF was added 1N NaOH (0.22 mL, 0.22 mmol) and then methanol (2 mL). The yellow solution was stirred for 1.5 hours and then 1N HCl (0.22 mL, 0.22 mmol) was added. The reaction mixture was evaporated in vacuo to a white solid. This solid was dissolved in ethyl acetate and water. The organic layer was dried briefly over MgSO4 and then concentrated to 1/6 original volume. An equal volume of hexane was added and the solid collected.

Workup

  1. customThe reaction mixture was evaporated in vacuo to a white solid
  2. dissolutionThis solid was dissolved in ethyl acetate
  3. dry with materialThe organic layer was dried briefly over MgSO4
  4. concentrationconcentrated to 1/6 original volume
  5. additionAn equal volume of hexane was added
  6. customthe solid collected

Sources & evidence

ORD record
ord-56d040af9355489eb2645bb3add2fa2e
Source dataset
uspto-grants-1994_05
Patent number
US05308853

Reaction notes

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