Triethylamine → HCID 19025374, compound

HRID 1033166Notes

Reaction equation

HRID 1033166 reaction equation
Cl[C:2]1([C:27]([F:30])([F:29])[F:28])[CH2:11][C:10]2[C:5](=[CH:6][C:7]([N:13]3[C:18](=[O:19])[CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[N:15]([CH3:24])[C:14]3=[O:25])=[C:8]([F:12])[CH:9]=2)[NH:4][C:3]1=[O:26].C(N(CC)CC)C>O1CCCC1>[F:12][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][C:7]=1[N:13]1[C:18](=[O:19])[CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[N:15]([CH3:24])[C:14]1=[O:25])[NH:4][C:3](=[O:26])[C:2]([C:27]([F:30])([F:28])[F:29])=[CH:11]2

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 19025376HCID 19025376, compound

Product 1

HCID 19025374HCID 19025374, compoundYield 47.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This compound was prepared in a manner analogous to that of Step H of Example 1, using 3.2 grams (0.007 mole) of 3-(3-chloro-6-fluoro-3,4-dihydro-3-trifluoromethylquinolin-2-on-7-yl)-1-methyl -6-trifluoromethyluracil and 3.2 grams (0.031 mole) of triethylamine in 100 mL of tetrahydrofuran. The product was recrystallized from ethanol, yielding 1.4 grams of 3-(6-fluoro-3-trifluoromethylquinolin-2-on-7-yl)-1-methyl-6-trifluoromethyluracil. The NMR spectrum was consistent with the proposed structure.

Workup

  1. customThis compound was prepared in a manner analogous to that of Step H of Example 1
  2. customThe product was recrystallized from ethanol

Sources & evidence

ORD record
ord-27efddbf08194c5b89a21d1af027a7ca
Source dataset
uspto-grants-1994_05
Patent number
US05310723

Reaction notes

Loading…