4-Methoxybenzylamine → HCID 18651508, compound

HRID 1033418Notes

Reaction equation

[CH3:1][C:2]([NH:36][C:37]([O:39]OCC1C=CC=CC=1)=[O:38])([CH3:35])[CH2:3][C:4]([NH:6][C@@H:7]1[CH2:13][CH2:12][C:11]2[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=2[N:9]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[C:26]([C:31]([OH:33])=O)=[CH:27][CH:28]=[CH:29][CH:30]=3)=[CH:21][CH:20]=2)[C:8]1=[O:34])=[O:5].[CH3:48][O:49][C:50]1[CH:57]=[CH:56][C:53]([CH2:54][NH2:55])=[CH:52][CH:51]=1>>[CH3:48][O:49][C:50]1[CH:57]=[CH:56][C:53]([CH2:54][NH:55][C:31]([C:26]2[C:25]([C:22]3[CH:21]=[CH:20][C:19]([CH2:18][N:9]4[C:10]5[CH:17]=[CH:16][CH:15]=[CH:14][C:11]=5[CH2:12][CH2:13][C@@H:7]([NH:6][C:4](=[O:5])[CH2:3][C:2]([NH:36][C:37]([O:39][CH2:12][C:11]5[CH:14]=[CH:15][CH:16]=[CH:17][CH:10]=5)=[O:38])([CH3:35])[CH3:1])[C:8]4=[O:34])=[CH:24][CH:23]=3)=[CH:30][CH:29]=[CH:28][CH:27]=2)=[O:33])=[CH:52][CH:51]=1

Participants

Reactant 2

HCID 754524-Methoxybenzylamine

HCID 86746770HCID 86746770, compound

Product 1

HCID 18651508HCID 18651508, compound

Procedure

The title compound was prepared from 4'-[[2,3,4,5-tetrahydro-3(R)-[[3-methyl-1-oxo-3-[[(benzyloxyoxy)carbonyl]amino]butyl]amino]-2-oxo-1H-1-benzazepin-1-yl]methyl][1,1'-biphenyl]-2-carboxylic acid (Example 72, Step B) and 4-methoxybenzylamine by the procedure described in Example 74, Step A. 1H NMR (200 MHz,CD3OD) 1.40 (s,6H), 2.00 (m,1H), 2.31 (m,1H), 2.50-2.75 (m,4H), 3.82 (s,3H), 4.27 (s,2H), 4.43 (dd;7,11 Hz;1H), 4.95 (d,15 Hz,1H), 5.05 (d,12 Hz,1H), 5.15 (d,12 Hz,1H), 5.37 (d,15 Hz,1H), 6.87 (m,3H), 7.03 (d,8 Hz,2H), 7.20-7.57 (m,19H). FAB-MS: calculated for C45H46N4O6 738; found 7.40.

Sources & evidence

ORD record: ord-1a0b6f557ff840dbae397087a9351ecf
Source dataset: uspto-grants-1994_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05310737

Reaction notes

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