Hydrochloric Acid → tert-Butyl 3-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)benzyl(2-methoxyethyl)carbamate
Reaction equation
[BH4-:40].[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH3:48][OH:49].[ClH:42].[F:1][c:2]1[c:3]([O:4][c:5]2[c:6]3[c:7]([n:8][cH:9][cH:10]2)[cH:11][c:12](-[c:14]2[cH:15][c:16]([CH2:17][N:18]([C:19]([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:25])[CH2:26][CH2:27][O:28][CH3:29])[cH:30][cH:31][cH:32]2)[s:13]3)[cH:33][cH:34][c:35]([N+:37]([O-:38])=[O:39])[cH:36]1.[Na+:41].[Ni:50]([Cl:51])[Cl:52]>>[F:1][c:2]1[c:3]([O:4][c:5]2[c:6]3[c:7]([n:8][cH:9][cH:10]2)[cH:11][c:12](-[c:14]2[cH:15][c:16]([CH2:17][N:18]([C:19]([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:25])[CH2:26][CH2:27][O:28][CH3:29])[cH:30][cH:31][cH:32]2)[s:13]3)[cH:33][cH:34][c:35]([NH2:37])[cH:36]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-09eb2642aef74e9183f6708163fcefeb
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
Loading…