Hydrochloric Acid → 6,7-Dihydro-5H-pyrrolo[3,4-b]pyridine--hydrogen chloride (1/2)

HRID 1033746Notes

Reaction equation

HRID 1033746 reaction equation
[NH:1]1[CH2:6][CH:5]=[CH:4][C:3]2[CH2:7][N:8](C(OCC)=O)[CH2:9][C:2]1=2.[ClH:15]>>[ClH:15].[ClH:15].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]2[CH2:7][NH:8][CH2:9][C:2]=12

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 18953638HCID 18953638, compound

Product 1

HCID 235036166,7-Dihydro-5H-pyrrolo[3,4-b]pyridine--hydrogen chloride (1/2)

Procedure

8.5 g (44 mmol) of ethyl 5,7-dihydro-1H-pyrrolo-[3,4-b]pyridine-6-carboxylate are refluxed overnight in 90 ml of concentrated hydrochloric acid. The solution is concentrated, the residue is stirred with acetone, and the salt is filtered off with suction and dried in the air.

Workup

  1. concentrationThe solution is concentrated
  2. filtrationthe salt is filtered off with suction
  3. customdried in the air

Sources & evidence

ORD record
ord-63017100ea8c47909c247d8996c1ec16
Source dataset
uspto-grants-1994_05
Patent number
US05312823

Reaction notes

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