Chloroacetone → HCID 19025027, compound

HRID 1033937Notes

Reaction equation

HRID 1033937 reaction equation
Cl.[NH2:2][C:3]([CH3:10])([CH3:9])[C:4]([O:6][CH2:7][CH3:8])=[O:5].C(N(CC)CC)C.Cl[CH2:19][C:20](=[O:22])[CH3:21]>CC(N(C)C)=O>[O:22]=[C:20]([CH3:21])[CH2:19][NH:2][C:3]([CH3:10])([CH3:9])[C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

5

Reactant 3

HCID 6571ChloroacetoneHCID 8471TriethylamineHCID 22343822Ethyl 2-amino-2-methylpropanoate hydrochloride

Product 1

HCID 19025027HCID 19025027, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

430 g (2.56 mol) of ethyl 2-aminoisobutyrate hydrochloride was dissolved in 2 l of DMAc, and 652 g (6.46 mol) of triethylamine and 373 g (4.03 mol) of chloroacetone were added thereto. The mixture was stirred and reacted under nitrogen stream at 80° C. for 3 hours. After completion of the reaction, the reaction solution was poured into 20 l of ice water and extracted twice with 2 l of ethyl acetate. The extracted solution was treated by a conventional method to obtain 402 g (yield: 84%) of the desired product.

Workup

  1. customreacted under nitrogen stream at 80° C. for 3 hours
  2. customAfter completion of the reaction
  3. extractionextracted twice with 2 l of ethyl acetate
  4. additionThe extracted solution was treated by a conventional method

Sources & evidence

ORD record
ord-d3bdd677296e4d5c959c7e9878222aa7
Source dataset
uspto-grants-1994_05
Patent number
US05312929

Reaction notes

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