Hydrogen Bromide → 2-Amino-7-hydroxytetralin hydrobromide

HRID 1033952Notes

Reaction equation

HRID 1033952 reaction equation
Cl.[NH2:2][CH:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][C:7]([O:13]C)=[CH:8][CH:9]=2)[CH2:4]1.C(OCC)C.[BrH:20]>C(O)(C)C>[BrH:20].[NH2:2][CH:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][C:7]([OH:13])=[CH:8][CH:9]=2)[CH2:4]1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 147509157-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride

Product 1

HCID 147509162-Amino-7-hydroxytetralin hydrobromide

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A suspension of the compound obtained in step (b) (6.6 g) in 48% hydrobromic acid (80 ml) is refluxed for 2 hours. The obtained solution is evaporated to dryness and the residue is twice taken up in absolute ethanol and concentrated to dryness. An oily product is thus obtained which is dissolved in hot isopropanol (20 ml). Ethyl ether (30 ml) is added thereto and a crystalline precipitate of 2-amino-7-hydroxytetralin hydrobromide (6.8 g) is obtained. M.p. 171°-173° C.

Workup

  1. temperatureis refluxed for 2 hours
  2. customThe obtained solution is evaporated to dryness
  3. concentrationconcentrated to dryness
  4. customAn oily product is thus obtained which

Sources & evidence

ORD record
ord-18bf23df7b564c1e8c7fed68f48f933e
Source dataset
uspto-grants-1994_05
Patent number
US05312961

Reaction notes

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