反应详情

温度

60 °C

A mixture of ethyl 4-[3-(4-hydroxybenzoyl)indol-1-yl]butyrate (0.50 g), 1-bromo-2,2-dimethyl-1-(4-isobutylphenyl)propane (0.74 g) and potassium carbonate (0.59 g) in N,N-dimethylformamide (10 ml) was stirred at 60° C. for 20 hours. The reaction mixture was filtered, and the filtrate was poured into a mixture of ethyl acetate and 0.5N hydrochloric acid. The organic layer was separated, washed with water, and dried over magnesium sulfate. After evaporation of the solvent, the residue was purified by column chromatography on silica gel eluting a mixture of n-hexane and ethyl acetate (5:1) to give ethyl 4-[3-[4-[2,2-dimethyl-1-(4-isobutylphenyl)-propyloxy]benzoyl]indol-1-yl]butyrate (376 mg) as an oil.

1. filtrationThe reaction mixture was filtered
2. additionthe filtrate was poured into a mixture of ethyl acetate and 0.5N hydrochloric acid
3. customThe organic layer was separated
4. washwashed with water
5. dry with materialdried over magnesium sulfate
6. customAfter evaporation of the solvent
7. customthe residue was purified by column chromatography on silica gel eluting
8. additiona mixture of n-hexane and ethyl acetate (5:1)