反应详情

A mixture of ethyl 4-[3-(4-hydroxybenzoyl)indol-1-yl]butyrate (176 mg), 1-(1-bromohexyl}-4-isobutylbenzene (223 mg) and potassium carbonate (207 mg) in N,N-dimethylformamide (4 ml) was stirred at room temperature for 6 hours. The reaction mixture was filtered and the filtrate was poured into a mixture of ethyl acetate and 0.5N hydrochloric acid. The organic phase was separated, washed with water and brine, dried over magnesium sulfate and evaporated. The residue was chromatographed on silica gel column eluting with a mixture of n-hexane and ethyl acetate (3:1) to give ethyl 4-[3-[4-[1-(4-isobutylphenyl)hexyloxy]benzoyl]indol-1-yl]-butyrate (279 mg) as an oil.

1. filtrationThe reaction mixture was filtered
2. additionthe filtrate was poured into a mixture of ethyl acetate and 0.5N hydrochloric acid
3. customThe organic phase was separated
4. washwashed with water and brine
5. dry with materialdried over magnesium sulfate
6. customevaporated
7. customThe residue was chromatographed on silica gel column
8. washeluting with a mixture of n-hexane and ethyl acetate (3:1)