Potassium Carbonate → HCID 13365961, compound

HRID 1034150Notes

Reaction equation

HRID 1034150 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9](=[O:11])(=[O:10])[N:8]([CH2:12][CH2:13][CH2:14][CH2:15]Br)[C:7](=[O:17])[C:6]=2[CH:18]=1.[N:19]1[CH:24]=[CH:23][CH:22]=[N:21][C:20]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[N:19]1[CH:24]=[CH:23][CH:22]=[N:21][C:20]=1[N:25]1[CH2:30][CH2:29][N:28]([CH2:15][CH2:14][CH2:13][CH2:12][N:8]2[C:7](=[O:17])[C:6]3[CH:18]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=3[S:9]2(=[O:11])=[O:10])[CH2:27][CH2:26]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 887471-(2-Pyrimidinyl)piperazineHCID 13365982HCID 13365982, compound

Product 1

HCID 13365961HCID 13365961, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.02 mol of 5-fluoro-2-(4-bromobutyl)-1,2-benz-isothiazol-3(2H)one 1,1-dioxide and 0.02 mol of 1-(2-pyrimidinyl)piperazine are stirred with 0.02 mol of K2CO3 in 150 ml of absolute DMF at 100° C. for 1 hour. The mixture is then evaporated. Water is added and the organic substance is taken up in methylene chloride. The dried CH2Cl2 phase is applied to asiatic gel column and eluted with CH2Cl2 /CH3OH (95:5).

Workup

  1. customThe mixture is then evaporated
  2. additionWater is added
  3. washeluted with CH2Cl2 /CH3OH (95:5)

Sources & evidence

ORD record
ord-fe399b5cecbb4c8096e94352e14d915e
Source dataset
uspto-grants-1994_05
Patent number
US05314884

Reaction notes

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