Piperazine → 5-Iodo-2-(piperazin-1-yl)pyrimidine

HRID 1034153Notes

Reaction equation

HRID 1034153 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([I:8])=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1>CN(C)C=O>[I:8][C:5]1[CH:4]=[N:3][C:2]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:7][CH:6]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 17142232-Chloro-5-iodopyrimidine

Product 1

HCID 157298765-Iodo-2-(piperazin-1-yl)pyrimidine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.02 mol of 2-chloro-5-iodopyrimidine, 0.06 mol of piperazine and 100 ml of absolute dimethylformamide are heated to 100° for 45 minutes and then evaporated. The crystalline residue is shaken with potassium bicarbonate solution and methylene chloride. The substance contained in the methylene chloride phase is purified by column chromatography over silica gel 60. The amine obtained by elution with methylene chloride/methanol (7:3) is stirred with isopropyl ether and filtered off with suction.

Workup

  1. customevaporated
  2. customis purified by column chromatography over silica gel 60

Sources & evidence

ORD record
ord-e1a754807c274522b13f9f470c93da15
Source dataset
uspto-grants-1994_05
Patent number
US05314884

Reaction notes

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