HCID 67794992, compound → HCID 67821643, compound

HRID 1034243Notes

Reaction equation

HRID 1034243 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][C:30]=1[Cl:31])[O:5][C:6]([NH:8][C@H:9]1[C:13](=[O:14])[N:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:11][C@H:10]1[C:21]([O:23]C(C)(C)C)=[O:22])=[O:7]>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][C:30]=1[Cl:31])[O:5][C:6]([NH:8][C@H:9]1[C:13](=[O:14])[N:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:11][C@H:10]1[C:21]([OH:23])=[O:22])=[O:7]

Participants

3

Reactant 1

HCID 67794992HCID 67794992, compound

Product 1

HCID 67821643HCID 67821643, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The tert-butyl ester of Example 13 is dissolved in trifluoroacetic acid and stirred for 16 h at room temperature after which time the reaction is concentrated in vacuo. The resulting material is purified by chromatography on silica gel eluting with EtOH/CH2Cl2 /HOAc to give the title compound.

Workup

  1. concentrationis concentrated in vacuo
  2. customThe resulting material is purified by chromatography on silica gel eluting with EtOH/CH2Cl2 /HOAc

Sources & evidence

ORD record
ord-569db8c4262f4670aae55fb9c51bf7b8
Source dataset
uspto-grants-1994_05
Patent number
US05314886

Reaction notes

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