Hydrochloric Acid → (S)-5-Methyl-3-nitromethyl-hexanoic acid monopotassium salt

HRID 1034571Notes

Reaction equation

HRID 1034571 reaction equation
C([O:3][C:4](=[O:15])[CH2:5][C@@H:6]([CH2:11][N+:12]([O-:14])=[O:13])[CH2:7][CH:8]([CH3:10])[CH3:9])C.[OH-].[K+:17].Cl.[Cl-].[K+]>O>[K+:17].[CH3:9][CH:8]([CH3:10])[CH2:7][C@H:6]([CH2:11][N+:12]([O-:14])=[O:13])[CH2:5][C:4]([O-:15])=[O:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 4873Potassium ChlorideHCID 14797Potassium HydroxideHCID 29984078(S)-5-methyl-3-nitromethyl-hexanoic acid ethyl ester

Product 1

HCID 87239685(S)-5-Methyl-3-nitromethyl-hexanoic acid monopotassium salt

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

830 mg of (S)-5-methyl-3-nitromethyl-hexanoic acid ethyl ester (VIII, R1=ethyl) were suspended in 0.8 mL of H2O. 900 mg of 50% aqueous KOH were added. After 5 h at 25° C. conversion was complete (determination by HPLC). 4.2 mL of 1M aqueous HCl were added and the solvent was removed under reduced pressure to give a solid consisting of the title compound and KCl.

Workup

  1. customthe solvent was removed under reduced pressure
  2. customto give a solid

Sources & evidence

ORD record
ord-b7eda5d63df049cc95cd00179f98041d
Source dataset
uspto-grants-2013_10
Patent number
US08546112B2

Reaction notes

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