反应详情

A solution of 5-amino-3-methyl-1-phenylpyrazole (8.66 g, 50 mmol) in acetic acid (70 mL) was treated with cyclohexanone (10.6 mL, 100 mmol) at ambient temperature for 40 hours. The volatiles were removed and the residue diluted with water and 10% sodium hydroxide added until the pH=12. The mixture was stirred with 10 mL of hexane for 30 minutes and the solid collected by filtration, washed with water and hexane and dried to give 9.43 g (74%) of the title compound. MS (DCI): m/z 254 (M+H)+.

1. customThe volatiles were removed
2. additionthe residue diluted with water and 10% sodium hydroxide
3. additionadded until the pH=12
4. filtrationthe solid collected by filtration
5. washwashed with water and hexane
6. customdried