HCID 136654070, compound → HCID 136414507, compound

HRID 1034971Notes

Reaction equation

HRID 1034971 reaction equation
[O:1]=[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]2[C:12]([C@H:20]3[CH2:24][CH2:23][CH2:22][N:21]3C(OCC3C=CC=CC=3)=O)=[N:13][N:14]([CH2:15][C:16]([F:19])([F:18])[F:17])[C:4]=2[NH:3]1>C(O)(C(F)(F)F)=O>[NH:21]1[CH2:22][CH2:23][CH2:24][C@@H:20]1[C:12]1[C:5]2[C:6]3[CH2:7][CH2:8][CH2:9][CH2:10][C:11]=3[C:2](=[O:1])[NH:3][C:4]=2[N:14]([CH2:15][C:16]([F:19])([F:18])[F:17])[N:13]=1

Participants

3

Reactant 1

HCID 136654070HCID 136654070, compound

Product 1

HCID 136414507HCID 136414507, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of Example 69D (0.55 g, 1.16 mmol) in TFA (10 ml) was heated at 50° C. for 6 h. Volatile were removed and the residual was purified by HPLC (C-18, 0-100% gradient CH3CN with 0.1% TFA in water with 0.1% TFA) to provide Example 69E. MS (DCI): m/z 341 (M+H)+.

Workup

  1. customVolatile were removed
  2. customthe residual was purified by HPLC (C-18, 0-100% gradient CH3CN with 0.1% TFA in water with 0.1% TFA)
  3. customto provide Example 69E

Sources & evidence

ORD record
ord-9ea9744af409480f9218bb51ef91578c
Source dataset
uspto-grants-2013_10
Patent number
US08546368B2

Reaction notes

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