Hydrochloric Acid → HCID 67247992, compound

HRID 1035318Notes

Reaction equation

HRID 1035318 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[C@@H:10]([CH2:21][CH:22]([O:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[Br:31])[CH3:23])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>ClCCl>[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][C@@H:10]([CH2:21][CH:22]([O:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[Br:31])[CH3:23])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67248278HCID 67248278, compound

Product 1

HCID 67247992HCID 67247992, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of Example 252D in dichloromethane (3 mL) was added HCl (4 M dioxane, 4 mL). The reaction was stirred for 4 hours before the reaction solution was concentrated. NaOH (1 M 10 mL) and dichloromethane (10 mL) were added, and the organic layer collected. Purification via flash chromatography (0-30% methanol/dichloromethane) afforded the title compound.

Workup

  1. concentrationwas concentrated
  2. additionNaOH (1 M 10 mL) and dichloromethane (10 mL) were added
  3. customthe organic layer collected
  4. customPurification via flash chromatography (0-30% methanol/dichloromethane)

Sources & evidence

ORD record
ord-ecf7a080018c4a1ea4abdf2b0eee1e92
Source dataset
uspto-grants-2013_10
Patent number
US08546377B2

Reaction notes

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