Methylamine → HCID 59443448, compound

HRID 1035626Notes

Reaction equation

HRID 1035626 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([O:22][CH3:23])[CH:18]=3)[CH:13]=2)[CH:11]=1)[C:6](O)=[O:7].[CH3:24][NH2:25]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([O:22][CH3:23])[CH:18]=3)[CH:13]=2)[CH:11]=1)[C:6]([NH:25][CH3:24])=[O:7]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 59443487HCID 59443487, compound

Product 1

HCID 59443448HCID 59443448, compoundYield 28%

Procedure

The compound was prepared by reaction of 3-methoxy-5-(6-methoxy-naphthalene-2-yl)benzoic acid (500 mg, 1.62 mmol, 1 eq) with 33% methylamine solution (1 eq) according to method D. Purification by column chromatography with hexane/ethyl acetate 1/1 as the eluent yielded the desired product in a yield of 28%, 148 mg.

Workup

  1. customPurification by column chromatography with hexane/ethyl acetate 1/1 as the eluent

Sources & evidence

ORD record
ord-cdef42942964487d945b6091196ae624
Source dataset
uspto-grants-2013_10
Patent number
US08546392B2

Reaction notes

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