HCID 24950390, compound → HCID 24949870, compound

HRID 1035673Notes

Reaction equation

HRID 1035673 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([OH:18])[CH:13]=3)[CH:8]=2)[C:3]=1/[CH:19]=[CH:20]/[C:21]([NH:23][CH3:24])=[O:22]>CCCCCC.C(OCC)(=O)C.[OH-].[OH-].[Pd+2]>[OH:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([OH:18])[CH:13]=3)[CH:8]=2)[C:3]=1[CH2:19][CH2:20][C:21]([NH:23][CH3:24])=[O:22]

Participants

4

Reactant 1

HCID 24950390HCID 24950390, compound

Product 1

HCID 24949870HCID 24949870, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 21226206Ethyl acetate hexaneSolvent

Procedure

(E)-3-(2-Hydroxy-6-(3-hydroxyphenyl)naphthalene-1-yl)-N-methylacrylamide is stirred over night with Pd(OH)2 in ethanol/THF 2/1 (1.5 ml) under a hydrogen atmosphere at RT. The reaction mixture is filtered, and the solvent is removed in vacuum on a rotary evaporator. The desired product was obtained in quantitative yield.

Workup

  1. filtrationThe reaction mixture is filtered
  2. customthe solvent is removed in vacuum on a rotary evaporator

Sources & evidence

ORD record
ord-f312483994354f51a6f4970b1c47b8ab
Source dataset
uspto-grants-2013_10
Patent number
US08546392B2

Reaction notes

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