Formic Acid → (2R,3S)-3-(Tert-butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane

HRID 103588Notes

Reaction equation

HRID 103588 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]([C:10]([CH2:11][Cl:12])=[O:13])[CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[CH3:24][CH2:25][N:26]([CH2:27][CH3:28])[CH2:29][CH3:30].[CH3:31][CH2:32][O:33][C:34](=[O:35])[CH3:36].[CH:21]([OH:22])=[O:23].[Cl:37][Rh+:38][C:39]1=[C:47]([CH3:48])[C:45]([CH3:46])=[C:43]([CH3:44])[C:40]1([CH3:41])[CH3:42]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]([CH:10]([CH2:11][Cl:12])[OH:13])[CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1

Participants

6

Reactant 5

HCID 284Formic AcidHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 9922259tert-butyl N-(1-benzyl-3-chloro-2-oxo-propyl)carbamateHCID 178425026HCID 178425026, compound

Product 1

HCID 4712659(2R,3S)-3-(Tert-butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane

Sources & evidence

ORD record
ord-80fb14a261d2452d81de5d59af10fd2c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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