反应详情

To a solution of N,N-dimethylformamide (2.81 mL) in dichloromethane (40 mL) was added dropwise POCl3 (2.78 mL) at 0° C. The reaction mixture was warmed up to room temperature and spiro[4.5]decan-8-one (3.95 g) in dichloromethane (5 mL) was added dropwise. The mixture was stirred overnight. The reaction was quenched with cold aqueous sodium acetate and the resulting mixture was extracted with ether and the organic layer was dried over Na2SO4, filtered, and concentrated to provide the title compound.

1. customThe reaction was quenched with cold aqueous sodium acetate
2. extractionthe resulting mixture was extracted with ether
3. dry with materialthe organic layer was dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated