Hydrochloric Acid → 3-Nitro-4-(piperidin-4-ylamino)benzenesulfonamide

HRID 1035903Notes

Reaction equation

HRID 1035903 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([S:10](=[O:13])(=[O:12])[NH2:11])[CH:7]=[CH:6][C:5]=1[NH:14][CH:15]1[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]1)([O-:3])=[O:2].Cl>ClCCl.CCOCC>[N+:1]([C:4]1[CH:9]=[C:8]([S:10]([NH2:11])(=[O:12])=[O:13])[CH:7]=[CH:6][C:5]=1[NH:14][CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)([O-:3])=[O:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67126453HCID 67126453, compound

Product 1

HCID 433458063-Nitro-4-(piperidin-4-ylamino)benzenesulfonamide

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

Tert-butyl 4-(2-nitro-4-sulfamoylphenylamino)piperidine-1-carboxylate was dissolved in dichloromethane (3 mL) and treated with 1N HCl in ether (4 mL). The reaction was stirred overnight then concentrated to give the title compound.

Workup

  1. concentrationthen concentrated

Sources & evidence

ORD record
ord-7afd8d7da9a74f74adca6ddf5f88d4e4
Source dataset
uspto-grants-2013_10
Patent number
US08546399B2

Reaction notes

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